Bristol-Myers Squibb and AstraZeneca strengthens diabetes alliance

WorldPharmaNews reported that Bristol-Myers Squibb company announced today that they will acquire biopharmaceutical company Amylin Pharmaceuticals Inc.

Following BMS’s acquisition of Amylin, BMS and Astra Zeneca will enter into collaboration arrangements, based on the framework of the existing diabetes alliance, regarding the development and commercialisation of Amylin’s portfolio of products.

AstraZeneca will make a payment to Amylin, as a wholly owned subsidiary of Bristol-Myers Squibb, in the amount of approximately $3.4 billion in cash. Profits and losses arising from the collaboration will be shared equally.

Lamberto Andreotti, chief executive officer, Bristol-Myers Squibb said “The acquisition of Amylin by Bristol-Myers Squibb is also a unique way for Bristol-Myers Squibb and AstraZeneca to expand the alliance between the two companies, and it demonstrates Bristol-Myers Squibb’s innovative and targeted approach to partnerships and business development.

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Aesica creates 100 jobs on Sheppey

Kent Online have reported that Aesica the pharmaceutical company is creating up to 100 jobs on the Isle of Sheppey.

Aesica is creating the jobs at its Queenborough plant over the next three years as the site is prepared for major expansion. The latest development follows the opening last year of a £3m Potent Manufacturing Facility.  Aesica will be looking for candidates with a manufacturing background who are keen to pursue a career or apprenticeship in the pharmaceutical industry.

Simon Clough, managing director of Aesica Formulated Products, said: “This is an exciting time for Aesica and the local community. Not only are we growing as a business, we’re also creating up to 100 new jobs which is a fantastic boost for the region’s economy.

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P&G help London clean up for the Olympics!

SuperSavyMe has reported that P&G has teamed up with the Mayor of London to bring the P&G Capital Clean Up campaign to help clean the capital before the London 2012 Olympic Games

The campaign started in March 2012 and over the last three months, Proctor and Gamble have hosted  a series of clean up events designed to bring Londoners together to spruce up neglected areas of the city as London gears up to host the Olympic games.

The events so far have involved clearing the region of 1,000 bags of litter, removing unsightly graffiti, and restoring swathes of habitat. The public can get involved by signing up to participate in one of the organised clean up events at www.pgcapitalcleanup.com

P&G are official sponsors of the London Olympic Games.

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Leading engineering technology could monitor hip replacements for signs of wear

The Engineer has reported that new leading technology could monitor hip replacements for signs of wear, powered by the movement of the user’s walk.

The device which has been engineered is designed to fit inside a typical prosthetic hip joint, uses a piezo-electric device that generates up to 3.7V of electricity as the user walks to power a strain gauge and a transmitter.   The device contains a ball bearing that rolls back and forth as the user walks along and strikes a substrate covered on one side with piezo-electric material (known as a unimorph) to produce electricity.

Hopefully this new device will be able to tell doctors if the replacement is starting to break down and advise the patient on lifestyle changes or the potential need for another operation. This will hopefully prolong the life of some replacements or at least signal when it is time for a new one, before the patient is in pain.

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Research says that men who drink 7 cups of tea a day are 50% more likely to develop prostate cancer

The Telegraph reported that a research study at Glasgow University  has said that men who drink a lot of tea a day are 50 per cent more likely to develop prostate cancer

Glasgow University found that people who drink more than seven cups of tea are at a much higher risk of getting the disease than those who consume three cups or fewer.

The warning comes after scientists at the University of Glasgow tracked the health of more than 6,000 men for four decades.  The participients were aged between  21 and 75 were asked to complete a questionnaire about their usual consumption of tea, coffee and alcohol as well as their smoking habits and general health, and had to attend a screening examination.

Dr Kate Holmes, head of research at The Prostate Cancer Charity, said: ‘Whilst it does appear that those who drank seven or more cups of tea each day had an increased risk of developing prostate cancer, this did not take into consideration family history or any other dietary elements other than tea, coffee and alcohol intake……It is therefore unclear as to whether there were other factors in play which may have had a greater impact on risk.

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Merck sign $303 million biotherapeutics deal

PharmaTimes has reported that Merck & Co has entered into a possible $303 million USD collaboration with Ambrx to develop ‘smart bomb’ antibodies.

Merck hope to develop biologic drug conjugates using Ambrx’s “site-specific protein medicinal chemistry technology”

Merck is paying an upfront fee of $15 million and is eligible to receive milestones totalling up to $288 million. Ambrx will also receive royalties.

Richard Murray, head of biologics and vaccines research at Merck said that this collaboration will allow us to combine Ambrx’s expertise in site-specific protein conjugation chemistry with Merck’s expanding antibody capabilities and extensive small molecule resources.

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UK manufacturing to get £6.5m through R&D projects

The Engineer has reported that UK manufacturing is to receive a £6.5m innovation boost through 16 new research and development projects to develop new production technologies

The Engineering and Physical Sciences Research Council and the Technology Strategy Board are to provide grant funding to support the development of new technologies that have the potential to underpin new production processes in a wide range of industrial applications and market sectors. The research will focus on novel manufacturing processes and techniques, resource efficiency and greater environmental sustainability through the efficient disposal or recycling of asset.

Companies including Airbus Operations, GKN Aerospace and Unilever will lead the projects, which will lead to technologies such as innovative car-painting methods, autonomous intelligent machining, the online control of welding processes using ultrasonic test techniques, and sustainable and resource-efficient titanium cutting.

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Cambridge Science Park Acquired by US Giant

As reported by Business Weekly, the US real estate investment company, BioMed Realty Trust, has acquired Granta Park, a leading science park based in Cambridge for £126.8m.

Currently, the Cambridge-based Science Park as 11 lab and office buildings and it’s tenants include some of the worlds leading pharma and biotech organisations including Gilead Sciences, UCB and Vernalis. The investment from BioMed Realty will also current tenant relationships with companies such as MedImmune and Pfizer to be extended.

Speaking of the agreement, BioMed Realty stated, “The Cambridge UK research community is anchored by the University of Cambridge, established in 1209, with 20 per cent of the world’s Nobel Prize recipients in medicine and chemistry and the recipient of over 280 million pounds in research grants in 2011.

“This Cambridge science cluster supports over 1,000 science and technology companies, the Wellcome Trust, the largest medical research charitable organisation in the world, Cavendish Laboratory, and the Babraham Institute.”Cambridge Science Park Acquired by US Giant

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UK offshore wind could create 215,000 Jobs

The Bloomsberg Business week reported that the U.K. offshore wind industry could create 215,000 jobs and boost exports by up to 22.5 billion pounds by 2030.

The Centre for Economics and Business Research said in a report commissioned by Irish wind developer Mainstream Renewable Power Ltd that the Development of the industry may “see an annual 1 percent uplift” in gross domestic product.  The estimates are based on the installation of 49 gigawatts of offshore wind by 2030 resulting in 97,000 jobs created by 2020, assuming offshore wind generation reaches 17 gigawatts.

Mainstream Renewable’s Chief Executive Officer Eddie O’Connor said “By creating a new industry, offshore wind will create jobs, assist in balancing the trade deficit and boost GDP at a time of economic uncertainty,”

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Scientists have grown human bone from stem cells

The Telegraph has reported that scientists have succeeded in growing human bone from stem cells in a laboratory, which they claim may eventually pave the way for patients to have broken bones repaired or replaced with new ones grown outside the body.

The researchers started with stem cells taken from fat tissue. It took around a month to grow them into sections of fully-formed living human bone up to a couple of inches long.  The technology, which has been developed along with researchers at the Technion Institute of Research in Israel, uses three dimensional scans of the damaged bone to build a gel-like scaffold that matches the shape.

The first trial in patients is on course to be conducted later this year, by an Israeli biotechnology company Bonus BioGroup that has been working with academics on the technology.

Professor Avinoam Kadouri, head of the scientific advisory board for Bonus BioGroup, said: “There is a need for artificial bones for injuries and in operations…..We use three dimensional structures to fabricate the bone in the right shape and geometry. We can grow these bones outside the body and then transplant it to the patient at the right time”

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Norwegian oil services firm Aker Solutions to create 1300 new jobs in London

The Telegraph reported that Norwegian oil services firm Aker Solutions says it aims to build up a 1 700-strong London engineering hub thereby creating 1 300 new jobs by 2015, as growth in global oil and gas markets drives demand for the company’s technologies and services.

Aker Solutions provides oilfield products, systems and services for customers in the oil and gas industry, and is listed on the Oslo stock exchange. The company, which employs more than 3000 people in the UK, opened a new office in Chiswick Park, West London, last year.

UK Prime Minister David Cameron said: “Aker Solution’s decision to create 1300 new jobs at a new engineering hub in Chiswick is great news for the local economy and it is a vote of confidence in the skill, expertise and professionalism of our engineering sector.”

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Scientists develop eco friendly carbon catalysts

The Engineer has reported that Norwegian Scientists are developing carbon catalysts that could be used instead of precious metals to speed up chemical reactions.

The 3.2million EU-backed FREECATS (carbon nanostructures as metal free catalysts) project is aiming to develop environmentally friendly catalysts that can be used in fuel cells, water purification and the production of light olefins.  The scientists will attempt to build carbon structures on the atomic scale that are capable of binding or transforming substances in certain ways.

Catalysis is one of the major consumers of precious metals, such as platinum. However, platinum group metals are not usually found naturally in Europe therefore European countries rely on imports.  Bu using alternative catalysts Prof Magnus Rønning of Norwegian University of Science and Technology  said, ‘the European dependency on precious metals will ease and therefore the dependency on less stable countries to supply these’.

The three-year project commenced in April 2012 and the team hopes the first catalysts will be available by the end of this year. There are 9 European research institutions and technology enterprises are working on the project, which is being coordinated by the Norwegian University of Science and Technology.

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Dr Reddy’s Laboratories and Merck team up to develop biosimilars

As reported by The Wall Street Journal, the generic drug company, Dr Reddy’s Laboratories is to team up with Merck Serono’s biopharmaceutical division to develop biosimilars to be sold in the U.S, Europe and Japan.

The partnership will see the two companies co-develop a portfolio of biosimilars and will focus mainly on monoclonal antibodies. Dr Reddys and Merck Serono will work together to co-develop, manufacture and commercialise the compounds around the world.

Dr Reddy’s are a leader in the development of biosimilars and their partnership with Merck Serono will further strengthen their presence in the biosimilar space in emerging markets.

The deal will seek to benefit from a new market due to patents on biotech drugs expiring. Historically, these medicines have been safe from generic competition, however, the development  of biosimilar versions of these drugs could mean that high quality, low cost versions of the biotechnology drugs will soon become widely available.

Merck is hoping to protect itself from this risk by collaborating with Dr Reddy’s to develop co-molecules. Under the

Dr Reddy’s Laboratories and Merck team up to develop biosimilars

agreement, Dr Reddy’s will lead the early product development and complete Phase 1 development, before handing it over to Merck for manufacturing and late-stage Phase III trials.

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Cambridge, Hertfordshire and Norwich receive a slice of £250m Bioscience Boost

As reported by Business Weekly, five bioscience centres in Cambridge, Hertfordshire and Norwich will receive a large slice of the government’s £250m investment into the bioscience industry, as announcement by David Willetts, the Universities and Science Minister.

The £250m has been allocated by the Biotechnology and Biological Sciences Research Council, and is the first of a five year strategic investment programme.

The research establishments who will receive the bioscience cash injection include:

It is hoped that the £250m investment into our already outstanding UK biosciences industry, will help keep the United Kingdom at the forefront of the global bioscience industry.  The investment will also help ensure that the UK can meet the challenges of feeding the growing global population in a sustainable way, as well as finding alternatives to fossil fuels and supporting the ageing population. Not forgetting the support the investment will provide to highly skilled bioscience jobs.

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Cambridge, Hertfordshire and Norwich receive a slice of £250m Bioscience Boost

 

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Product Compliance Head Job in East Midlands

Naynesh Mistry at CK Science is currently recruiting for a Product Compliance Head to join a global pharmaceutical company at their site based in the East Midlands on a permanent basis.

Product Compliance Head Job Description

As Product Compliance Head, you will manage the compliance across the 3 production units, ensuring that all aspects of the handling, manufacturing and distribution of pharmaceutical products comply with the requirements of the Quality Manual and Policies and meet all relevant cGMP regulatory and legislative requirements

The purpose of this Product Compliance Head position is to provide technical leadership for the site in all product quality compliance related matters and ensure operational business comply with cGMP legal and regulatory requirements.

Key responsibilities of this Product Compliance Head job will include:

  • Ensure that all aspects of the handling, manufacturing and distribution of pharmaceutical products at the site comply with the requirements of the Pharma Corporate Quality Manual and Policies and meet all relevant cGMP regulatory and legislative requirements.
  • Ensure that the local Quality System and Standard Operating Procedures are in place and that compliance with cGMP
  • Ensure that a high quality of products is achieved through qualification and validation based upon quality risk analysis.
  • Ensure that the QA department maintains an innovative approach based on improvement, implementation of best practice.
  • Provide leadership, direction and support to the people within the QA Compliance area and ensure that they are qualified, achieve a high level of competence, are motivated and carry out their duties in a safe manner.
  • Maintain current knowledge of local and international regulatory and legislative requirements and trends to ensure that expert advice and appropriate technical support on product quality related matters is provided to the whole site.
  • Ensure that all components, drug product containers, closures, in process materials, packaging material, labelling and drug products are released in accordance with the registered specifications.
  • Manage complaints, recalls, counterfeits and product tampering according to the company Corporate Quality Manual.

To be considered for this Product Compliance Head position, you will have the following qualifications, skills and experience:

  • A degree in Sciences or equivalent
  • Experience in Quality Assurance and Quality Control and/or in manufacturing environment within the Pharmaceutical industry.
  • Previous experience in API manufacture and ICH guidelines are preferred, however experience within secondary pharmaceutical manufacture will also be considered if you show the technical and managerial skills required for this role.
  • Sound knowledge of pharmaceutical regulatory requirements and be familiar with international guidelines, including FDA and MHRA.

Naynesh Mistry - Scientific Recruitment Consultant at CK Science

Please contact Naynesh for more details.

How to apply:

Please click here to apply online now.

For more information regarding this Product Compliance Head position, please contact Naynesh Mistry at CK Science on 0114 283 9956 or email nmistry@ckscience.co.uk. Please quote reference SH24328 in all correspondence.

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50 jobs created – Worcestershire Science Park

As reported by the Malvern Gazette, after an agreed £4m government investment, fifty new science jobs are to be created at Malvern Hills Science Park in Worcestershire, UK.

Opened in 1997, there are 30 technology and science-based companies based at the science park, which employs 300 people. However, the science park is now full to capacity and as Simon Geraghty, Deputy Leader of the County Council explains, the investment “…is a big step forward and really significant piece of funding that will allow the science park and grow and take on more jobs.”

 

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GSK acquire Cellzome for £61 million

The Telegraph have reported that GSK  today, announced that it has entered an agreement to acquire Cellzome for £61 million in which they already own a 20pc stake.

Cellzome is the leader in the development and advancement of proteomics technologies. It currently has labs in Cambridge in the UK and Heidelberg in Germany. GSK currently own 19.98 % equity in the company but they will now assume full control of Cellzome. It will become part of GSK’s R&D organisation.

John Baldoni, senior vice-president of Platform & Technology Science at Glaxo, said: “The acquisition of Cellzome adds significantly to our scientific capabilities and capacity to characterise drug targets, and provides the opportunity to further enhance Glaxo’s ability to bring medicines to patients in a more effective manner.”

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Assay Development Scientist Job in Wiltshire, UK

Reena Dhana at CK Science is currently recruiting for an Assay Development Scientist to join a rapidly expanding Diagnostic Technology Organisation at their site based in Wiltshire. This Assay Development Scientist job is a full time, permanent and fixed term role.

Assay Development Scientist Job Description:

As an Assay Development Scientist, the main purpose of your role will be:

– Contributing to assay development.

– Formulating reagents.

– Testing of assays.

The successful Assay Development Scientist, you will have the following qualifications, skills and experience:

– Qualified in Biochemistry, Molecular Biology or a related discipline (or equivalent).

– Previous experience of PCR, ELISA or other assay techniques.

– Previous experience of writing scientific publications.

– Previous laboratory experience.

As an Assay Development Scientist, you will be joining a specialist Diagnostics Technology Organisation providing equipment to the Pharmaceutical and Biotechnology industries, this company is a growing organisation who are offering a competitive salary, with excellent benefits.

How to apply:

Contact Reena for more details.

Click here to apply online now.

For more information regarding this Assay Development Scientist role, please contact Reena Dhana at CK Science on 01438 723 500 or email rdhana@ckscience.co.uk. Please use reference ST24159 in all correspondence.

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Good news for gas industry as DECC advise that “fracking” should continue

The BBC News reported that the DECC have said that the gas extraction technique “fracking” should continue but with stricter conditions.

The technique “fracking” involves pumping water and chemicals into shale rock at high pressure to extract gas. The government sees shale gas as a valuable energy resource for the future.

Last year the company Cuadrillla had to stop fracking at its site the Bowland Basin in Lancashire as it was thought that it had caused seismic events in the area. The process was to be reviewed by the DECC, however the DECC expert review published yesterday concludes that it is safe to resume hydraulic fracturing provided that the recommended operating procedures are followed.

Cuadrilla’s Chief Executive Mark Miller said: We are pleased that the experts have come to a clear conclusion that it is safe to allow us to resume hydraulic fracturing, following the procedures outlined in the review.

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Offshore Group Newcastle to create 1000 jobs as it enters wind farm market

BBC news reported that Offshore Group Newcastle (OGN) is to create up to 1,000 new jobs after receiving a Government grant to build foundations for offshore wind farms.

DECC’s Offshore Wind Component Technologies Development and Demonstration Scheme will give OGN £640,250 to build the foundation structures for large wind turbine generators in waters over 30 metres (100ft) deep. The steel jacketed foundation, Triton, will be designed and developed by its subsidiary Aquind, at OGN’s new purpose-built facility at its Hadrian Yard in Wallsend.

OGN chief executive David Edwards said: “We are delighted to have been selected for this grant. Government support is especially vital in the early stages of project development……The offshore wind energy market is crucial to Britain’s future energy needs and we will do our utmost to ensure that this grant takes the UK into an even stronger role as the lead player in this sector.”

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