Senior Viral Vector Scientist - London
Jason Johal at CK Science is currently recruiting for a Senior Viral Vector Scientist to join a major new initiative to grow a cell therapy industry delivering health and wealth for the UK. Its vision is for the UK to be a global leader in the development, delivery and commercialisation of cell therapies, and a place where businesses can start, and confidently grow.
The company are currently developing a £55 million UK cell manufacturing centre to be based in Hertfordshire. The purpose of this facility will be the GMP manufacture of cell and gene products for Phase III clinical trials, to augment the current UK manufacturing capability, which is anticipated to reach capacity by 2017. This large scale manufacturing centre will supplement the process development and scale-up capabilities already established in-house at the companies development laboratories in London.
This has created a new opportunity for a Senior Viral Vector Scientist to work with the Industrial Viral Vector Lead to help play a pivotal role in delivering new therapies to the clinic.
The purpose of this role is to provide an expertise in the execution of viral vector industrialisation projects. The company's viral vector strategy will focus on the use of industrial bioprocessing techniques such as bioreactors and chromatography, to ensure supply of these critical materials for in vivo and ex vivo cell therapies. This role with provide technical expertise in one or more of these areas.
Your main responsibilities in this role will be:
- The delivery of viral vector process and analytical development projects through technical oversight of project, working with the Lead Scientist on experimental design and execution.
- Delivery of viral vector process and analytical development projects
- Assisting with costing of proposals for partners and support of BD function during new project scoping by providing technical support activities
- Strongly interacting with the Tech Transfer function and Project Managers to enable the development and tech transfer of viral vector processes
- Strongly interacting with academic and industry based groups to provide engineering solutions for vector cell line development, upstream and downstream bioprocessing
- Using in-depth knowledge of viral vector biology and bioprocessing to enable the Catapult to deliver robust and industrial processes
- Generating manufacturing and development protocols in relation in vivo and ex vivo gene therapy products to support technology development and regulatory submissions
- Providing input into the design and establishment of operating principles at the company's GMP manufacturing centre
You are required to have the following qualifications, skills and experience:
- Knowledgeable in the viral vector industrialisation and bioprocessing field
- Experience of upstream and downstream bioprocessing of viral vectors including viral vector biology and cell line development
- Experience of working with GMP regulations to manufacture viral vectors, cell therapies or other biologics
- Experience of cell culture of human and/or mammalian cell lines using a variety of bioreactors is essential
- Experience of chromatography, filtration and other separation / purification techniques is desirable
- Experience in the development of analytical assays suitable for use as characterisation, QC release methods and in-process controls is desirable
- Experience of tech transfer to/from commercial and research organisations
- Experience of viral vectors used in the ex vivo and in vivo modification of products is essential
- Experience of working closely with BD and partners to plan, cost and secure projects
- Experience in QMS is highly desirable
- Experience in writing and carrying out GMP production protocols is desirable
- Experience of delivering on agreed commercial objectives
- Validation, trouble shooting, development and scale-up to ensure regulatory-compliant novel medicinal products
- Extensive experience working in process development, scale-up or GMP manufacturing roles, at least part of which is within industry
- Proven ability to engage constructively with colleagues at all levels across different departments to deliver objectives A PhD ideally focusing on the production of viral vectors or bioprocessing is desirable (or equivalent)
If successful you will be joining a new initiative that is the UK's response to the translational gap between early-stage research and the later stages of clinical development in regenerative medicine and that will be shaping the UK cell therapy landscape.
For more information or to apply for this Senior Viral Vector Scientist position please contact Jason on +44 (0)1438 723 500 or email firstname.lastname@example.org. Alternatively, please click on the link below to apply online now.
CK Science is an Equal Opportunities employer.
Entitlement to work in the EEA is essential. Please quote reference ST33462.