Neurodegeneration Research Scientist - Surrey
Jason Johal is currently recruiting for a Neurodegeneration Research Scientist to join a dedicated team of scientists providing an outsourced service to one of the top ten largest pharmaceutical companies in the world. This role is based at the client's research and development site in Surrey which is commutable from London, Oxford, Reading and Guildford and is offered on a permanent basis with a salary of £32,000 to £40,000.
The mission of the group is discovering novel medicines for the treatment of Alzheimer's disease, Parkinson's disease, and other related neurodegenerative conditions. As such, you will investigate some of the key underlying mechanisms involved in neurodegenerative diseases and work closely with both internal and external collaborators.
The successful candidate is expected to have a good knowledge of the cellular biology of neurodegenerative disease. In particular, expertise in neuronal cell culture and imaging techniques, ideally related to tau, alpha-synuclein or other mis-folded protein mechanisms.
The main responsibilities of this role will be to:
- Develop the basic science (new areas of research, novel approaches, targets and techniques) to help the company expand its capabilities in neurodegenerative disease
- Maintain and manipulate immortalised cell lines, primary, iPSC or brain slice cultures and performing biochemical or functional assays in these cell models
- Work with complex cell systems (e.g. co-culture, organotypic culture) and using viral transfection, genetic manipulation, CRISPR/Cas9 to increase target validation for various molecular pathways
- Work with complex gene expression (or other '-omics') datasets (e.g. RNA-seq, Nanostring) to investigate various molecular pathways
- Design, validate, troubleshoot, and perform molecular, biochemical and cell-based assays to address key molecular mechanisms and test new chemical entities
- Perform assays that might include: RT-PCR, Fluorescence Polarization, AlphaScreen, ELISA, MSD, SDS-PAGE, WB, High-Content Imaging
- Measure biochemical or functional parameters in cells using techniques including microscopy, calcium imaging, live fluorescence imaging of organelle trafficking, immunocytochemistry, morphology, live/dead cell assays
You are required to have the following qualifications, skills and experience:
- BSc, MSc or Ph.D. in a neuroscience-related subject or equivalent.
- A Strong background in mammalian cell culture including primary cultures, organotypic brain slice or iPSCs.
- A good understanding and/or experience of assay development
- A good knowledge of genetics and common molecular mechanisms contributing to neurodegeneration
- The ability to prepare and present data at external meetings, experience and track record of presenting and/or publication of data
Our client has 7,000 employees who work just within the Research Laboratories, spanning more than 50 countries worldwide and are the 7th largest investor in R&D in the UK within the pharmaceutical sector. The successful candidate will be a full time fixed term employee of the CK Group and will be working for CK as part of a very busy, productive team of scientists that CK provide for our client as an outsourced function. As such they must be able to demonstrate enthusiasm, dedication and self-motivation together with the desire to acquire new skills.
For more information or to apply for this Neuroimmunology role please contact Jason Johal on 01438 723500 or email email@example.com. Alternatively please click on the link below to apply online. Please note that your CV should show exact dates of employment (month and year) and any gaps of a month or more should be explained.
CK Group is an Equal Opportunities employer and welcomes applications from all who meet our selection criteria.
If you do not hear back from us within 5 working days of your application for this role, it means that on this occasion you have not been shortlisted for the next stage of the recruitment campaign. Entitlement to work in the EEA is essential. Please quote reference 45274 in all correspondence.