Posts Tagged ‘science news’

Novartis’s rare cancer drug is launched in the UK

Tuesday, September 11th, 2012

Pharmatimes have reported that Novartis have launched their new drug Jakavi which means for the first time patients in the UK with a rare form of blood cancer will now have access to this targeted therapy

Jakavi (ruxolitinib) is a first-in-class JAK 1 and JAK 2 inhibitor, and is now available to treat patients in the UK with disease-related enlarged spleen or various forms of myelofibrosis, which affects around 0.34-0.76 people in every 100,000.

Myelofibrosis is a rare, potentially life-threatening blood cancer characterised by bone marrow failure, enlarged spleen and debilitating symptoms including extreme fatigue, poor quality of life and weight loss, and shortened survival.

Jakavi received EU approval at the end of August 2012

 

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Olympic Team GB work with scientists on gene tests for injuries

Thursday, July 26th, 2012

As reported by the BBC, Scientists behind Olympic Team GB are working on genetic tests to understand why some athletes are prone to injury

Scientists at the Institute for Human Health and Performance at University College London are currently researching how and why tendon injuries and stress fractures occur as they are common in elite athletes

University College London’s Prof Hugh Montgomery says they have found a gene they think strongly influences the risk of stress fracture…….If we understood that genetic component we would have a much better understanding of the patho-physiology – the disease processes that let that happen”

The study has been working with the English Institute of Sport (EIS), which aims to apply the latest in sports science and medicine for the benefit of Britain’s Olympic and Paralympic athletes.

EIS’s Director of Sport Science, Dr Ken van Someren said “If we can identify some particular genes that are associated with a higher risk of injury in certain individuals, and we think we’re close, we can tailor the training, conditioning and preparation that we put those individuals through.”

 

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GSK supports Olympics anti doping operation

Monday, July 16th, 2012

The Guardian has reported that GSK today marks its role as Official Laboratory Services Provider for the London 2012 Olympic and Paralympic Games by launching its first UK advertising campaign to celebrate the role that anti-doping science will play in helping ensure this summer’s Games are the cleanest possible.

The multimillion-pound ad campaign features a string of British athletes, including Marlon Devonish and Phillips Idowu to highlight its role running the anti-doping testing laboratory for the London Olympic games.

The London 2012 anti-doping laboratory, provided by GSK in partnership with the London Organising Committee for the Olympic and Paralympic Games (LOCOG) and King’s College London opened today and will be operational 24 hours a day, seven days a week. More tests will be carried out at the London 2012 lab, based at GSK’s Harlow site, than at any other Games with every medallist and up to 50 per cent of all competing athletes being tested.

 

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A Biorenewables Development Centre has opened in York

Monday, July 9th, 2012

The BBC has reported that the Bio renewables Development Centre (BDC) a new facility designed to make the UK a world leader in green chemistry has opened at the University of York.

The Bio renewables Development Centre (BDC) hopes to bridge the gap between laboratories and the chemicals industry. This is essential as chemicals derived from plants are expected to play an important role in the future as oil supplies decline. The centre received £2.5m funding from the government.

The centre’s director, Joe Ross, said the facility aimed to help the industry make the transition from petroleum-based chemicals to renewable feedstocks. “At the University of York, we have had two centres – one based in biological sciences, the other in chemistry – that are doing a lot of R&D within what we call biorenewables, so using plants or microbes to make useful stuff……….cver recent years, we have realised that we need to have a centre that allows us to scale-up that process. And the result is the BDC.”

 

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GSK and Theravance receive positive data for their COPD pill

Tuesday, July 3rd, 2012

PharmaTimes have reported that GlaxoSmithKline and Theravance have reported positive data from four Phase III trials assessing a combination therapy for maintenance treatment of COPD, making the once-daily pill closer to a regulatory filing.

The clinical trials involved more than 4,000 patients, including two 24-week efficacy trials comparing a combination of the long-acting muscarinic antagonist (LAMA) umeclidinium bromide and the long-acting beta-agonist (LABA) vilanterol. The date showed statistically significant improvements when compared with placebo and the individual parts in both trials, which tested difference doses.

Darrell Baker, SVP Respiratory Portfolio Optimisation Leader at GSK said “We are very encouraged by the results of these initial studies for our LAMA/LABA, an important cornerstone of our broad respiratory development portfolio…. These studies, together with our earlier dose-ranging work, give us confidence that this is a once-daily medicine with the potential to benefit many patients with COPD.

 

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Bristol-Myers Squibb and AstraZeneca strengthens diabetes alliance

Monday, July 2nd, 2012

WorldPharmaNews reported that Bristol-Myers Squibb company announced today that they will acquire biopharmaceutical company Amylin Pharmaceuticals Inc.

Following BMS’s acquisition of Amylin, BMS and Astra Zeneca will enter into collaboration arrangements, based on the framework of the existing diabetes alliance, regarding the development and commercialisation of Amylin’s portfolio of products.

AstraZeneca will make a payment to Amylin, as a wholly owned subsidiary of Bristol-Myers Squibb, in the amount of approximately $3.4 billion in cash. Profits and losses arising from the collaboration will be shared equally.

Lamberto Andreotti, chief executive officer, Bristol-Myers Squibb said “The acquisition of Amylin by Bristol-Myers Squibb is also a unique way for Bristol-Myers Squibb and AstraZeneca to expand the alliance between the two companies, and it demonstrates Bristol-Myers Squibb’s innovative and targeted approach to partnerships and business development.

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MCerts level 2 Environmental Consultant – Dublin

Monday, July 2nd, 2012

Barney Smith at CK Science is recruiting for a MCerts level 2 qualified Environmental Consultant for an Environmental Testing and Monitoring company in Dublin on a permanent basis.

Responsibilities:

As an Environmental Consultant you will be responsible for air monitoring and stack emissions testing on a number of different sites based around the Dublin area.

Qualifications:

The successful candidate for this Environmental Consultant role must be qualified to minimum MCerts level 2 and have completed parts 1-4 within the course.

The company:

The company operate across the UK and Ireland, as a dedicated stack emissions testing contractor, providing independent advice and support to manufacturing and process sites in compliance with environmental legislation.

Barney Smith - Manager at CK ScienceHow to apply:

Apply online:

For more information or to apply for this MCerts level 2 Environmental Consultant position please contact Barney Smith on 0191 384 8905 or email bsmith@ckscience.co.uk. Please quote reference DH24652 in all correspondence.

 

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Leading engineering technology could monitor hip replacements for signs of wear

Monday, June 25th, 2012

The Engineer has reported that new leading technology could monitor hip replacements for signs of wear, powered by the movement of the user’s walk.

The device which has been engineered is designed to fit inside a typical prosthetic hip joint, uses a piezo-electric device that generates up to 3.7V of electricity as the user walks to power a strain gauge and a transmitter.   The device contains a ball bearing that rolls back and forth as the user walks along and strikes a substrate covered on one side with piezo-electric material (known as a unimorph) to produce electricity.

Hopefully this new device will be able to tell doctors if the replacement is starting to break down and advise the patient on lifestyle changes or the potential need for another operation. This will hopefully prolong the life of some replacements or at least signal when it is time for a new one, before the patient is in pain.

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Manufacturing Engineer – Hertfordshire

Monday, June 25th, 2012

Reena Dhana at CK Science is currently recruiting for a Manufacturing Engineer to join a Global Chemical Manufacturing Organisation at their site in Hertfordshire on a full time, 6 – 8 month contact.

Responsibilities:

As a Manufacturing Engineer the main purpose of your role will be:

  • Designing, installing and commissioning of new production processes and equipment
  • Troubleshooting and developing existing areas as well as providing support on process related issues to the manufacturing and quality teams.

Qualifications:

As a Manufacturing Engineer you will have the following qualifications, skills and experience:

  • Degree / HNC in Production, Mechanical, Chemical Engineering or a related discipline (or equivalent)
  • Proven practical experience within a Manufacturing or Process Engineering function in a Chemical Manufacturing industry
  • Knowledge of Manufacturing Methodologies (e.g. 6 Sigma, Lean) and Process Control Equipment / Systems (e.g. SCADA, PLC, Eurotherm) is essential

As a Manufacturing Engineer, you will be joining a Global Chemical Manufacturing Organisation who in return is offering a competitive salary.

Reena Dhana - Consultant at CK ScienceHow to apply:

Apply online:

For more information or to apply for the role of Manufacturing Engineer please contact Reena Dhana on 01438 723 500 or email rdhana@ckscience.co.uk.  Alternatively please. Please quote reference ST24576 in all correspondence.

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Merck sign $303 million biotherapeutics deal with Ambrx

Tuesday, June 19th, 2012

PharmaTimes has reported that Merck & Co has entered into a possible $303 million USD collaboration with Ambrx to develop ‘smart bomb’ antibodies.

Merck hope to develop biologic drug conjugates using Ambrx’s “site-specific protein medicinal chemistry technology”

Merck is paying an upfront fee of $15 million and is eligible to receive milestones totalling up to $288 million. Ambrx will also receive royalties.

Richard Murray, head of biologics and vaccines research at Merck said that this collaboration will allow us to combine Ambrx’s expertise in site-specific protein conjugation chemistry with Merck’s expanding antibody capabilities and extensive small molecule resources.

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