Experience required:

As DMPK Scientist you will require experience in the following:

• Competency in conducting in vitro DMPK assays such as intrinsic clearance (microsomes and/or hepatocytes) and/or plasma protein binding.
• An understanding of basic LC-MS/MS principles and preparing samples for LC-MS/MS analysis
• Routine LC-MS/MS troubleshooting and maintenance

Qualifications and skills:

The successful DMPK Scientist will have the following qualifications and skills:

• Degree (or equivalent) in a scientific capacity
• Some knowledge and experience of working within a DMPK department
• LC/MS/MS experience with Waters Triple Quad instruments is desired
• Competency with Excel

Benefits:

If successful for this DMPK Scientist job, you will be joining a global Drug Discovery company and in return there is an attractive salary, coupled with excellent benefits and career progression opportunities.

How to apply:

Apply online:

For more information or to apply for this DMPK Scientist position, please contact Julie Marshall via email: jmarshall@ckscience.co.uk or telephone: 01438 723 500.  Please quote reference ST24197 in all correspondence.

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Responsibilities:

As an Engineering Manager, the main purpose of your role will be:

• Guiding projects for Capital Investment.
• Accountable for end to end delivery of projects from initiation through to Closure.
• Ensuring the projects are resourced according including looking at manage risks, schedules and approved budgets to ensure successful deliveries
• Ensuring Good Engineering Practices (GEP) are used in the design, installation and commissioning of assets
• Undertaking Change Management, Deviation Investigations, Corrective Action and Preventative Action (CAPA) activities and root cause analysis (RCA)

Qualifications and skills:

As an Engineering Manager, you will have the following qualifications, skills and experience:

• HND in an engineering discipline (or equivalent)
• Extensive experience in the Project Management in GMP, ideally in manufacturing and/or packaging
• Demonstrable experience in managing projects from small scale to multi million pounds
• Previous experience with contract and budget development, cost control, negotiation and execution
• Proven understanding and familiarity of FDA and MHRA guidance for solid dosage form facility design and operation, cGMP and H&S regulations

Benefits:

As an Engineering Manager, you will be joining a Global Pharmaceutical Organisation who in return is offering a competitive salary with an excellent benefits package.

How to apply:

Apply online now

For more information or to apply for the role of Engineering Manager please contact Reena Dhana on 01438 723 500 or email rdhana@ckscience.co.uk.  Please quote reference ST24022 in all correspondence.

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Skills required:

The ideal candidate for this Analytical Chemist role will have proven experience in working in an analytical laboratory type role involving method qualification or validation, release testing of drug substances or stability testing.

Qualifications: 

The successful candidate for this Analytical Chemist role ideally will be qualified to Degree level or similar in a relevant scientific discipline and have some experience gained with in a GMP setting.

How to apply:

Apply online for this role

For more information or to apply for this Analytical Chemist role please contact Heather Deagle at CK Science on 0191 384 8905 or email hdeagle@cksicience.co.uk. Please quote reference DH23844 in all correspondence.

Register your CV with us now

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Responsibilities:

As a Quality Assurance Auditor you will ensure compliance to cGMP of all activities related to the development of pharmaceutical products for use in Clinical Trials, including the Quality Management systems and you will carry out Quality compliance reviews/release of Investigational Medicinal Products for use in Clinical Trials. Other duties will include auditing and approving procedures and documents from manufacturing, analytical, packaging and service groups, reviewing and approving equipment and facilities qualification, training others as appropriate and assisting with external audits as required.

Qualification and Skills:

The ideal candidate for this Quality Assurance Auditor role will hold a BSc in a Life Science subject (or equivalent) and will have experience gained within relevant departments of Pharmaceutical companies, preferably Quality Assurance. You will have a good working knowledge of cGMPs. An understanding of Clinical Supplies requirements would be advantageous.

How to apply:

For more information or to apply for this Quality Assurance Auditor role please contact Reena Dhana on 01438 723 500 or email rdhana@ckscience.co.uk.  Please quote reference DH23538 in all correspondence.

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During the research study middle-aged mice treated with the vitamin for six weeks underwent changes in their eyes that led to improved vision. Levels of amyloid beta, a toxic protein linked to Alzheimer’s disease and known to be a hallmark of ageing, were also reduced in the animals’ eyes and blood vessels.

Lead scientist Professor Glen Jeffery, from the Institute of Ophthalmology at University College London, said: “Finding that amyloid deposits were reduced in the blood vessels of mice that had been given vitamin D supplements suggests that vitamin D could be useful in helping to prevent a range of age-related health problems, from deteriorating vision to heart disease.”

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UK scientists recently found the route malaria uses to enter blood cells. They hope to target this pathway in a new approach to developing a vaccine against malaria, which kills hundreds of thousands of people a year. Several potential malaria vaccines are already being tested in clinical trials; although no vaccine has yet been licensed for use.

One possibility is to exploit a recently-discovered potential weakness in the parasite’s life cycle. A team at the Sanger Institute found in November that a single receptor on the surface of red blood cells and a substance known as “PfRh5″ on the parasite are crucial to the success of malaria in invading blood cells.

Early lab tests suggest a vaccine against the protein may prove effective, at least in animals. Dr Sandy Douglas is a Wellcome Trust Clinical Research Training Fellow from the University of Oxford told the BBC: “We have found a way of making antibodies that kill all different strains of malaria parasites. This is still early phase research in animals. The next step is to do clinical trials in people.”

If safety tests of the vaccine prove successful, clinical trials in patients could begin within the next two to three years, says the Oxford team.

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The role:

Duties of this Product Technologist role will involve the completion of activities concerned with supporting the current business (Cephs, Liquid Inhalations and Topicals) or supporting the introduction of new products, processes and equipment into production, primarily focused on development, scale up and tech transfer activities. There may be opportunities for permanent positions during or on completion of the project.

Responsibilities:

Key responsibilities of this Product Technologist role will include:

• Organisation of manufacturing, filling and packaging development trials and validation activities.
• Operation and cleaning of pilot scale manufacturing equipment.
•  Development of robust manufacturing, filling and cleaning processes.
• Physical testing of laboratory samples and interpretation of generated data.
• Preparation of documents and reports.
• Use of problem solving techniques to resolve issues and develop suitable processes.
•  Interaction with a variety of business functions such as QA, Regulatory and Production.
•  Collation, recording and analysis of experimental data.

Qualification’s & experience needed:

Job requirements for this Product Technologist role include:

• Knowledge of manufacturing, tech transfer and production processes
• Graduate calibre preferably in a Science degree or related scientific subject
• Extensive experience in a solid dose, liquid inhalations or topical manufacturing environment
• Experience in a similar FMCG role will also be considered
• Experience in a technical, manufacturing or quality function
•  A team player with a flexible approach who is able to make informed decisions when faced with aggressive time scales
• Ability to present information, both written and verbally, in a clear and accurate manner
• Appreciation of Safety and Quality requirements and good working knowledge of GMP

How to apply:

For more information or to apply for this Product Technologist role please contact Carrie-Ann Bell on 0191 384 8905 or email cbell@ckscience.co.uk.  Please quote reference DH22995 in all correspondence.

                                                          Click here to apply now!

Piramal specialise  in the manufacture of active pharmaceutical ingredients and current export more than 100 of these products worldwide. The company will be using the investment to help increase its competitive edge when trading internationally. This was explained by Site Lead, Jarrett Palmer,  “This is most welcome news. The funding will go a long way towards supporting our ambitious growth plans over the next five years. The grant will enable us to invest in new capabilities which will enable us to enter new markets worldwide.”

Investment was also received by Aesica Pharmaceuticals Ltd and Precision Hydraulic Cylinders (UK) Ltd.

This great news for manufacturing in the North East and enables innovative companies such as these to thrive in the global economy.

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The news comes as a result of a reorganisation of their R&D operations following their acquisition of Genzyme, as well as the loss of exclusivity on key drugs.

Sanofi plans to group their R&D into four ‘research hubs’ to be based in the US (Boston). France, Germany and Asia. It is hoped that this move will help to improve communication between teams and help integrate R&D operations.

As a result, both sales and R&D jobs will be cut, however, there is no news yet as to exactly how many jobs will be cut.

Like other pharmaceutical companies, in recent times, Sanofi has been taking strides to cut back staff in more mature markets (e.g. Europe and US) and is concentrating on strengthening it’s workforce in emerging markets. In fact, since 2008, Sanofi has created more that 3,700 jobs in these countries.

This news comes just as The Wall Street Journal, reports a 26 per cent rise in Sanofi’s third quarter profit which was boosted by sales in emerging markets.

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As Andrew Witty, CEO of GSK explains, the plan comes are a result of tax breaks on innovation introduced by Chancellor George Osbourne,  ‘Because of changes in the UK tax regime, it will be our intention to bring more activity to Britain and take advantage of the situation here and increase our contribution to Britain. If it [corporation tax] is going to come down over the next few years, it will attract us to pay more tax here.’

The global pharma are considering Cumbria, County Durham and two locations in Scotland for their new factory. A decision is expected to be made in May.

Looking for a new position in the Pharmaceutical Industry? Click here to search our current pharmaceutical jobs now.

Responsibilities:

The ideal candidate for this Senior Analytical Chemist role will provide analytical support to the development and manufacture of a wide range of dosage forms from early formulation studies and clinical trial manufacture to NDA registration. This role will be very varied and includes method development and validation, provision of support during formulation development and manufacture, release testing and stability studies.  The nature of the environment is fast paced. As such you would have a number of projects to work on at any one time spanning a diverse product, dosage form and client range. With this in mind good organisational skills are essential.

Qualifications:

The successful candidate for this Senior Analytical Chemist role must be qualified in Chemistry or a related subject (or equivalent) and previous laboratory experience, preferably in pharmaceutical analytical development is required. Proven experience in HPLC method development and validation are essential. Also the ideal candidate will have experience of working to cGLP / GMP and will have used the techniques as described above as well as GC, UV and dissolution techniques.

How to apply:

For more information or to apply for this Senior Analytical Chemist  please contact Jason Johal on 01438 723 500 or jjohal@ckscience.co.uk.   Please quote reference ST22590 in all correspondence.

                                                       Click here to apply online now!

The QinetiQ Group, based in Farnborough, is selling off its fuel and lubricants business for £500,000, reports insidermedia.com.

The Intertek Group is to take over the UK Fuel and Lubricants Testing Business (OALTB), which QinetiQ has sold in order to concentrate on their core services, including aerospace and security. Intertek is going to bring the fuel business into the pharmaceutical and chemical division of their operations.

This is the third recent acquisition by Intertek, who have also purchased Stoke based Food Analytical Laboratories Limited (FAL) and Rechere Developpement and Consulting (RDC), based in Brussels. Wolfhart Hauser, CEO of Intertek, has said the purchases “demonstrate Intertek’s progress in its strategy to add new expertise and capabilities across the supply chain.” He later commented that the firm is looking forward “to welcoming these companies and their management teams to Intertek.”

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pharmacy benefits companies

Pharmaceutical companies are beginning to worry that due to the proposed $29 billion deal that will see Express Scripts buy Medco Health Solutions, drug prices could decrease, affecting the pharamceutical compnies profits. Most who have commented on the deal, including Eli Lilly’s CFO Dernica Rice, have played down the impact the buy-out will have, with Rice saying Lilly could maintain its negotiation power through their products advantage over the generic drugs on the market.

However, Michael Luby, of BioPharma Alliance, believes the merger will mean the combined company would have “extraordinary purchasing power… [and] leverage [over] pharmaceutical companies.” Price cuts in Europe; particularly Germany and Spain, have been causing pharmaceutical companies problems, and having staved off effort from the US government over pricing, the big companies are now going to have to attempt to stop the private sector submitting the pharmaceutical sector to the same pricing measures.

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Nominate CK Science for the National Online Recruitment Awards (NORA’s) 2011!

 Nominations are currently being received for the awards, a prestigious honour created to recognise and reward excellence in the recruitment industry.

 This is something we always strive for; we go to great lengths in order to help those in the science industry to find a job, particularly with our website, catered towards the internet savvy candidate of today. We have daily updates of all the latest jobs, industry updates and weekly video content, as well as expanding our presence on social networking sites, meaning that we can have constant communication and feedback from you, the candidate.

 If you believe CK Science deserves to be recognised at the NORA’s; click here or the banner above, it will be greatly appreciated!

The investment is expected to create up to 1,000 jobs in one of four UK plants, with Montrose thought to be the front runner due to the recent movement of biomanufacturing of several products from India to the Montrose plant. The Montrose factory also manufactures the products needed to make products that GSK inherited following its acquisition of Steifel in 2009.

Andrew Witty, GSK chief executive, praised the 280 staff at the Montrose factory for turning around what was an ailing site, up for sale at the turn of the Millennium, into a “globally competitive” production plant.

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Responsibilities:

As a global Neuroscience Principal Researcher, you will contribute to executing projects and will be expected to design and execute experiments independently and conduct research activities within established guidelines. You will also be expected to participate in discussion and review of new targets.

The role will include but will not be limited to the following activities:-

• The collection and collation of results and conclusions.
• Collaborating effectively with fellow project members to accomplish team goals in an efficient manner on time and within budget.
• Reviewing the effectiveness of current laboratory equipment and suggesting ways to better manage available equipment within research programs.
• Testing standard procedures to provide recommendations for improvement for use across programs.
• Contributing to information database development
• Contributing to the preparation and submission of patents, scientific publications and regulatory documents.

Skills and Qualifications:

The ideal candidate should have recognised expertise in a wide range of in vivo pharmacological techniques and the ability to conduct in vivo studies utilising biochemical and behavioural endpoints is critical. A general scientific background in the field of neurodegenerative disorders is also essential.

How to apply

For more information or to apply for this Biopharmacologist position, please contact Jason Johal on 01438 723 500 or jjohal@ckscience.co.uk.  Please quote reference ST22388 in all correspondence.

                                                         Click here to apply online

Responsibilities:

This role will involve carrying out analysis using techniques including Anderson Cascade Impaction and to ensure work is carried out in compliance to GMP. Other duties will include maintenance of equipment, taking part in internal and external QA assessments and completing paperwork amongst others.

Qualifications:

Candidates should be educated to degree level, or equivalent, in a relevant scientific subject and have experience of analysis of inhalation formulations.

Apply now:

For more information or to apply for this Inhalation Analyst position, please contact Hannah Milward on 0114 2839956 or hmilward@ckscience.co.uk.  Please quote reference SH22370 in all correspondence.

                                                        Click here to apply now!

A £12 million grant is to be made to ten promising researchers who are expected to become prominent in the field of cancer. It is intended to assist with the researcher’s careers and possible breakthroughs they could make. Two leading university lecturers, four scientists and four junior research scientists will be the recipients of the grant.

Applicants are being taken, with the deadline at the end of July drawing closer. Dr David Scott, director of science funding at Cancer Research UK, believes the grants show his organisation “is serious about supporting new scientists at the start of their careers.”

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If the Daresbury Science and Innovation Park is granted this status, then it could generate up to 10,000 skilled jobs and lead to £150 million investment. Holton Council leader Clr Rob Polhill has said the status would “take Daresbury to the next level.”

Around 100 companies have offices, workshops and laboratories on the site, and the massive investment would mean that even more specialist office, lab and technical spaces would be developed. The site opened in 2006 and is a world class centre for cutting edge sciences and high-tech businesses.

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Pharmaceutical company

The splitting of the animal health and baby formula businesses from the main company is the beginning of a process to unlock value within the company. Two other sectors will be kept in order to raise their value to $46 billion combined, though investors had hoped the company would split into five distinct divisions.

The two that have broken off were the obvious choices; the animal health business is worth nearly $4 billion so can stand on its own, and the nutrition side is the one that investors were most eager to see separate.

Though some investors may be disappointed that Pfizer hasn’t split all its divisions at once, it means that sectors that could not currently compete on their own have time to grow to the point where they can be world leaders in their own right, potentially creating a large number of jobs worldwide.

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A £14 million deal has been agreed in which Lundbeck will sell their site, which they closed during the recession. TryggPharma’s vice president of engineering Peter Harper has said the company is “very impressed with the facility [as it has] easy to access from Norway, Europe and our customers around the world”.

The facility is expected to employ 25 people within 12 months and the company has said there is a “commitment to invest and expand into the future of Teeside”. The North East Process Industry Cluster chief executive Stan Higgins has said the re-opening of the site is “great news for Teeside and for the pharmaceutical sector in particular”.

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As Associate Director, you will be responsible for developing and managing audit programs for healthcare compliance and privacy at the company’s facilities to ensure they are meeting the relevant company and regulatory standards.

As Associate Director, you will also:

• Develop and introduce a process for carrying out healthcare compliance audits. This will include the auditing procedure and the reporting of audit results and metrics to senior management. 
• Train company auditors in healthcare compliance auditing.
• Auditing company facilities including country offices and relevant business units for healthcare compliance.
• Develop and introduce a process for carrying out privacy audits. This will include the auditing procedure and the reporting of audit results and metrics to senior management.  The audits will check that the organization can both meet the requirements of the company and the relevant regulatory requirements.
• Train auditors in privacy auditing.
• Auditing facilities for privacy.

Person specification:

The ideal candidate for this Associate Director position will have the following qualifications, skills and experience:

• Possess a Bachelors degree (or equivalent) with related industry experience.
• Extensive experience in auditing
• Expert knowledge of healthcare compliance and/or privacy requirements for the pharmaceutical and/or medical device industries
• Strong written and oral communication skills.

How to apply

For more information or to apply for this Associate Director position, please contact Jason Johal at CK Science on 01438 723 500 or email jjohal@ckscience.co.uk. Please quote reference ST22200 in all correspondence.

Click here to apply online!

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Responsibilities:

As a Supply Manager reporting to the Logistics Manager of a busy manufacturing site and working alongside other Supply Managers, the successful applicant will be responsible for:

• The management of orders and forecasts with customers.
• Effectively responding to messages in Manugistics and SOLS alerts to ensure rapid response for customer requirements.
• Managing supply issues.
• Coordinate the resolution of supply issues (with Plant schedulers, QA and shipping) to ensure optimum delivery performance.
• Review Inventory Stock Policies to ensure effective stock management.

Person specification:

The ideal candidate will have excellent interpersonal skills and hold a qualification and/or have demonstrable experience within a planning environment.  Experience of MERPS and SAP is also desirable although not necessary. 

Apply now:

For more information or to apply for this Supply Manager role, please contact Graeme Pallas on 0191 384 8905 or gpallas@ckscience.co.uk.  Please quote reference DH22205 in all correspondence.

                                                   Click here to apply online now!

Executive chairman, Stefano Pessina thinks the tough conditions are likely to continue, and stated: “Looking to the year ahead, we are planning for consumer demand to be subdued and expect governments to continue to seek ways to contain growth in healthcare expenditure.”

Pessina also stared that as a group they will continue to focus their efforts on international expansion this year despite the challenging market conditions.

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Andrew Witty, chief executive of GSK is said to have not ruled out Montrose as a possible location for the new factory. The Montrose site current has 230 permanent and  50 part-time staff on it’s payroll.

Speaking of the Montrose site, Witty stated, “It is extraordinary to think that a few years ago the Montrose plant was close to shutting.

But the workforce applied great brain power to cost and process efficiently and now we are bringing work back from India – and Montrose is where it is going.

This is a workforce that has outmanoeuvred the threat of closure.”

Other sites shortlisted as possible locations for the new biopharmaceutical site include Barnard Castle, County Durham,  Irvine and Ulverston.

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Responsibilities:

Within this role you will provide analytical support to the development and manufacture of a wide range of dosage forms from early formulation studies and clinical trial manufacture to NDA registration. The work is very varied and includes method development and validation, provision of support during formulation development and manufacture, release testing and stability studies. 

Skills and experience:

You will have sufficient technical experience to be a driving force within the group and to be able to impart your knowledge to more junior members of staff.

• Communication skills:

It is likely that you will be the analytical representative for project teams and as such having strong communication skills, to be able to converse and build the clients confidence is essential.

• Organisational skills:

The nature of the environment is fast paced and as such you will have a number of projects to work on at any one time spanning a diverse product, dosage form and client range. With this in mind good organisational skills are also essential.

• Qualifications:

You must be qualified in Chemistry or a related subject (or equivalent) and have previous analytical/CMO laboratory experience (preferably in gained in pharmaceutical analytical development).

• Experience:

Experience in reversed phase HPLC / UV / DAD detection, GC, UV and dissolution, sample preparation (solid phase, liquid and solvent extraction) and proven experience in HPLC method development and validation are essential.

You will also have experience of working to cGLP / GMP.

Apply now

For more information or to apply for this Senior Analytical Method Development Scientist job, please contact Jason Johal at CK Science on 01438 732 500 or email jjohal@ckscience.co.uk. Please quote reference ST21688 in all correspondence.

The position will include laboratory-scale formulation development, the scale-up of potential formulations in a pilot facility, and involvement with technology transfer of development products into commercial manufacture in accordance with GMP.

Day to day you will be working on formulation development for new and existing products and monitoring them for physical/emulsion stability, pH and viscosity to find the optimum formulation. You will prepare supplies of Development Products for Accelerated Stability Studies by conducting manufacturing on a small scale for accelerated stability trials in a range of packaging materials and you will also prepare supplies of Development Products for Stability/Clinical Studies by manufacturing on a larger scale (up to 100 kg) at a pilot facility.

The ideal candidate will hold a degree/diploma or equivalent in a scientific discipline and will have Formulation experience gained preferably in pharmaceuticals/cosmetics or other skincare products. They will also have an appreciation of working in a GMP environment. Experience in the preparation of a range of new product formulations such as creams, gels, lotions and shampoos would be highly advantageous. Please note that semi solid formulations experience is essential.

Apply now

For more information or to apply for this Formulations Chemist job, please contact Jason Johal at CK Science on 01438 723 500 or email jjohal@ckscience.co.uk. Please quote reference ST21526 in all correspondence.

The company’s chief executive, Andrew Witty announced the news on Sky News. He stated that the scheme was not restricted to scientists, chemists and pharmacists, but will also be available to lawyers, economists and all of the other top class graduates that could help the pharmaceutical company.  He said, “The biggest reason we are doing this is that we want to get the absolute best possible graduates we can to work for GSK,” he told the programme. This is a great way for us to try and ensure we get that next brilliant scientist.”

As of next year, university tuition fees will triple for undergraduates so this is great news for budding scientists who are interested in working in the Pharmaceutical industry.

It is hoped that the announcement of GSK’s scheme will will encourage other companies to follow suit and help their recruits with crippling tuition fees. Thus ensuring that potential top talent will continue with their education.

GSK’s programme will costs them around £3 million per year and trainees will be required to stay with the company for several years until the fees have be repaid.

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The research and development centre will be closing down over the next two years. Speaking of the closure, Dr Ruth McKernan, the company’s head stated, “It is with a deep sense of sadness that we announce our proposal to exit our site in Sandwich, Kent.

“It has played an important role in the discovery and development of medicines and has brought many life-saving treatments to patients.”

The closure is part of a plan by the pharma company to partake in a global restructuring programme in order to, “to create a more focused and sustainable R&D engine for innovation”.

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Our Client is a Global Pharmaceutical Company currently recruiting for an Analytical Chemist for a Contract role within their QA Analytical Laboratory based in East London/Kent, UK.

Responsibilities:

Your main responsibilities will be to ensure accurate, timely and efficient analysis of materials being tested within the laboratory. Testing carried out will include wet chemical and instrumental analytical techniques, GC, HPLC, GLP and AA. Work will need to be carried out in line with the company’s policies on cGMP, Health and Safety, Quality Assurance and other specified policies. 

Your main duties will include following a test schedule to carry out analysis on materials, ensuring instrumentation and test methods are correctly maintained, preparing accurate reports of analytical results, maintaining stock levels for laboratory reagents and consumables. You will also be involved in preparing and modifying SOPs and general housekeeping and maintenance of the laboratory.

Person Specification:

To be considered for this role you will need to have a BSc in Chemistry or a related discipline (or equivalent). Previous experience in a QC or other analytical laboratory is essential. Knowledge and experience of major wet chemical and instrumental analytical techniques, GC and HPLC are also essential. Knowledge of pharmacopoeial testing, AA and GLP is desirable.

Apply Now

For more information or to apply for this Analytical Chemist position, please contact Jason Johal at CK Science on 01438 723 500 or email jjohal@ckscience.co.uk. Entitlement to work in the EEA is essential. Please quote reference ST21187 in all correspondence.

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