If you are considering working as an Interim and not going through PAYE you may have heard about IR35.
IR35 is an Inland Revenue initiative first introduced in approximately 1999 and was introduced to try and prevent people avoiding tax and Class 1 National Insurance Contributions (NICs).
IR35 became law in the year 2000 and it became apparent that one of its primary goals was to ensure that individuals working via limited companies would be subject to the same taxation laws as an individual performing the same tasks as a PAYE employee.
If you are seriously considering working as an Interim Scientific Contractor it is important to consider whether IR35 affects you and your situation. CK Science recommend that you discuss your situation and the contracts that you are undertaking with a suitably qualified accountant or a reputable Umbrella company to see if you are affected by the IR35 rules.
For more information about IR35 you may find the IR35 pages of the HMRC website a good starting point.